Cardiovascular
Cardiovascular Imaging Expertise
For more than 20 years, WorldCare Clinical has been a leading provider of Imaging for cardiovascular trials and device trials.

Experience Across Cardiovascular Indications
Our team has provided imaging CRO services on Phase I-IV drug and device trials across Cardiovascular indications, including:
- Acute and Chronic Heart Failure
- Acute Coronary Syndromes
- Acute Peripheral Arterial Occlusion
- Aneurysms
- Atrial Fibrillation
- Cardiac Surgery
- Carotid Artery Disease
- Congestive Heart Failure
- Coronary Artery Disease
- Fabry Disease
- Myocardial Infarction
- Pulmonary and Arterial Hypertension
Modalities
We have extensive experience with Cardiovascular studies in the U.S. and Europe involving the following modalities:- Angiography
- CT
- CTPA
- Echo
- MRA
- MRI
- PET and SPECT Myocardial Perfusion Imaging
- Pulmonary Angiography
- Transesophageal Echocardiograms (TEE)
- Ultrasound
- V/Q Lung Scan

Evaluation Criteria Expertise
We have experience with a variety of cardiovascular evaluation criteria, including:
- CAC Scoring
- Cardiac Morphology & Function
- Clip Placement
- Diastolic Pulmonary Artery Pressure
- Echo Assessments (Doppler, 2&3D Structure and Function, and Contrast Enhancement)
- Echo Peak TR Velocity
- Indirect Fick Cardiac Output (CO)
- LAA Assessments
- Lateral & Septal E/e’ Ratio
- Lateral & Septal e’ Velocity
- Left Atrial (LA) Volumes/Index
- Left Atrium Area & Diameter
- Left Atrium Longitudinal Strain
- Left Ventricle Ejection Fraction (LVEF)
- Left Ventricle end-diastolic volume (LVEDV)
- Left Ventricle end-systolic volume (LVESV)
- Left Ventricle Mass
- Left Ventricle Outflow Tract Stroke Volume
- Left Ventricle Septal/Posterior Wall Thickness
- Left Ventricular End Diastolic Pressure (LVEDP)
- Left Ventricular Longitudinal Strain
- Mean pulmonary artery pressure (mPAP)
- Mean right atrial pressure (mRAP)
- On-Study Incidental Findings
- Percentage of PV Stenosis
- Pulmonary Artery Pressure and Right Arterial Pressure
- Pulmonary Artery Wedge Pressure (PAWP)
- Quantitative Evaluation of PV and Stenosis
- Right Main PA Pulsatility
- Right Ventricle Ejection Fraction (RVEF)
- Right Ventricle End-Diastolic Volume (RVEDV)
- Right Ventricle End-Systolic Volume (RVESV)
- Right Ventricle Fractional Area Change & Tissue Doppler s’ Velocity
- Right Ventricle Global Longitudinal Strain (RVGLS)
- Right Ventricle Mass
- Right Ventricle Stroke Volume (RVSV)
- Right Ventricle: Left Ventricle Dimension Ratio & Area Ratio
- Right Ventricular Free Wall Strain
- Right Ventricular Outflow Tract Acceleration Time & Outflow Tract Notch Presence
- Safety Assessments
- Systolic Pulmonary Artery Pressure
- Thermodilution CO
- Tricuspid Annular Plane Systolic Excursion

Read Team
Our dedicated team of cardiologists and radiologists, technicians, regulatory experts, and project managers is among the most knowledgeable and well-respected in the industry. Our services also include safety monitoring. Our services also include safety monitoring. experts work with sponsors to design trials which ensure high-quality results in a cost-effective manner. We collaborate with sponsors in workflow design and imaging charter development to establish the foundation necessary to meet the sponsor’s clinical trial goals.Reader Training
Through a combination of our expert radiologists and our rigorous training and testing regimen, we are committed to increasing the accuracy and precision of data subject to blinded independent central review. Sponsors have the flexibility of working with our highly-trained in-house radiologists, with sub-specialty-trained board-certified radiologists from the Harvard Hospital System, or with other radiologists of the sponsor’s choice.

Study Design
Our experts work with sponsors to design trials which ensure high-quality results in a cost-effective manner. We collaborate with sponsors in workflow design and imaging charter development to establish the foundation necessary to meet the sponsor’s clinical trial goals.
Web-Based Technology Platform
Our state-of-the-art systems are 21 CRF Part 11 compliant and are used to analyze images from all modalities. The systems can be accessed by radiologists to perform assessments anywhere in the world. Thousands of clinical sites in the U.S., Latin America, Europe, and Asia-Pacific have uploaded imaging data directly into our secure system.

